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1

Vitagenes, cellular stress response, and acetylcarnitine: Relevance to hormesis

Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova-Kostova, Edward J. Calabrese

Journal:

Year:

2009

Language:

english

File:

PDF, 234 KB

english, 2009

2

Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond?

Jadkauskaite, Laura, Coulombe, Pierre A., Schäfer, Matthias, Dinkova-Kostova, Albena T., Paus, Ralf, Haslam, Iain S.

Journal:

Year:

2017

Language:

english

File:

PDF, 671 KB

english, 2017

3

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

Yagishita, Yoko, Fahey, Jed W., Dinkova-Kostova, Albena T., Kensler, Thomas W.

Journal:

Year:

2019

Language:

english

File:

PDF, 3.02 MB

english, 2019

4

Glucosinolates and isothiocyanates in health and disease

Albena T. Dinkova-Kostova, Rumen V. Kostov

Journal:

Trends in Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 842 KB

english, 2012

5

Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast

Cornblatt, B. S., Ye, L., Dinkova-Kostova, A. T., Erb, M., Fahey, J. W., Singh, N. K., Chen, M.-S. A., Stierer, T., Garrett-Mayer, E., Argani, P., Davidson, N. E., Talalay, P., Kensler, T. W., Visvana

Journal:

Year:

2007

Language:

english

File:

PDF, 313 KB

english, 2007

6

Curcumin and the cellular stress response in free radical-related diseases

Vittorio Calabrese, Timothy E. Bates, Cesare Mancuso, Carolin Cornelius, Bernardo Ventimiglia, Maria Teresa Cambria, Laura Di Renzo, Antonino De Lorenzo, Albena T. Dinkova-Kostova

Journal:

Molecular Nutrition & Food Research

Year:

2008

Language:

english

File:

PDF, 378 KB

english, 2008

7

Synthesis, Chemical Reactivity as Michael Acceptors, and Biological Potency of Monocyclic Cyanoenones, Novel and Highly Potent Anti-inflammatory and Cytoprotective Agents(1)

Zheng, Suqing, Santosh Laxmi, Y. R., David, Emilie, Dinkova-Kostova, Albena T., Shiavoni, Katherine H., Ren, Yanqing, Zheng, Ying, Trevino, Isaac, Bumeister, Ronald, Ojima, Iwao, Wigley, W. Christian,

Journal:

Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 1.28 MB

english, 2012

8

Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen

Albena T Dinkova-Kostova, Paul Talalay

Journal:

Free Radical Biology and Medicine

Year:

2000

Language:

english

File:

PDF, 91 KB

english, 2000

9

Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity

Vittorio Calabrese, Carolin Cornelius, Albena T. Dinkova-Kostova, Ivo Iavicoli, Rosanna Di Paola, Aleardo Koverech, Salvatore Cuzzocrea, Enrico Rizzarelli, Edward J. Calabrese

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

Year:

2012

Language:

english

File:

PDF, 2.02 MB

english, 2012

10

Sulforaphane mobilizes cellular defenses that protect skin against damage by UV radiation

Talalay, P., Fahey, J. W., Healy, Z. R., Wehage, S. L., Benedict, A. L., Min, C., Dinkova-Kostova, A. T.

Journal:

Proceedings of the National Academy of Sciences

Year:

2007

Language:

english

File:

PDF, 519 KB

english, 2007

11

Electrophilic tuning of the chemoprotective natural product sulforaphane

Ahn, Y.-H., Hwang, Y., Liu, H., Wang, X. J., Zhang, Y., Stephenson, K. K., Boronina, T. N., Cole, R. N., Dinkova-Kostova, A. T., Talalay, P., Cole, P. A.

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 863 KB

english, 2010

12

Extremely potent triterpenoid inducers of the phase 2 response: Correlations of protection against oxidant and inflammatory stress

Dinkova-Kostova, A. T., Liby, K. T., Stephenson, K. K., Holtzclaw, W. D., Gao, X., Suh, N., Williams, C., Risingsong, R., Honda, T., Gribble, G. W., Sporn, M. B., Talalay, P.

Journal:

Proceedings of the National Academy of Sciences

Year:

2005

Language:

english

File:

PDF, 528 KB

english, 2005

13

A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

Liby, K., Yore, M. M., Roebuck, B. D., Baumgartner, K. J., Honda, T., Sundararajan, C., Yoshizawa, H., Gribble, G. W., Williams, C. R., Risingsong, R., Royce, D. B., Dinkova-Kostova, A. T., Stephenson

Journal:

Cancer Research

Year:

2008

Language:

english

File:

PDF, 502 KB

english, 2008

14

Phytochemicals as Protectors Against Ultraviolet Radiation: Versatility of Effects and Mechanisms

Dinkova-Kostova, Albena

Journal:

Year:

2008

Language:

english

File:

PDF, 343 KB

english, 2008

15

Rhodiola roseaL.: from golden root to green cell factories

Marchev, Andrey S., Dinkova-Kostova, Albena T., György, Zsuzsanna, Mirmazloum, Iman, Aneva, Ina Y., Georgiev, Milen I.

Journal:

Phytochemistry Reviews

Year:

2016

Language:

english

File:

PDF, 848 KB

english, 2016

16

Semisynthetic flavonoid 7-O-galloylquercetin activates Nrf2 and induces Nrf2-dependent gene expression in RAW264.7 and Hepa1c1c7 cells

Roubalová, Lenka, Biedermann, David, Papoušková, Barbora, Vacek, Jan, Kuzma, Marek, Křen, Vladimír, Ulrichová, Jitka, Dinkova-Kostova, Albena T., Vrba, Jiří

Journal:

Chemico-Biological Interactions

Year:

2016

Language:

english

File:

PDF, 1.10 MB

english, 2016

17

NRF2 as an Emerging Therapeutic Target

Copple, Ian M., Dinkova-Kostova, Albena T., Kensler, Thomas W., Liby, Karen T., Wigley, W. Christian

Journal:

Oxidative Medicine & Cellular Longevity

Year:

2017

Language:

english

File:

PDF, 1.16 MB

english, 2017

18

Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases

Cuadrado, Antonio, Rojo, Ana I., Wells, Geoffrey, Hayes, John D., Cousin, Sharon P., Rumsey, William L., Attucks, Otis C., Franklin, Stephen, Levonen, Anna-Liisa, Kensler, Thomas W., Dinkova-Kostova,

Journal:

Nature Reviews Drug Discovery

Year:

2019

Language:

english

File:

PDF, 1.87 MB

english, 2019

19

Direct and indirect antioxidant properties of inducers of cytoprotective proteins

Albena T. Dinkova-Kostova, Paul Talalay

Journal:

Molecular Nutrition & Food Research

Year:

2008

Language:

english

File:

PDF, 978 KB

english, 2008

20

Synthesis and biological evaluation of 1-[2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]-4-ethynylimidazole. A novel and highly potent anti-inflammatory and cytoprotective agent

Tadashi Honda, Albena T. Dinkova-Kostova, Emilie David, Eric M. Padegimas, Chitra Sundararajan, Melean Visnick, Ron Bumeister, W. Christian Wigley

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 529 KB

english, 2011

21

Activation of the NRF2 Signaling Pathway by Copper-Mediated Redox Cycling of Para- and Ortho-Hydroquinones

Xiu Jun Wang, John D. Hayes, Larry G. Higgins, C. Roland Wolf, Albena T. Dinkova-Kostova

Journal:

Chemistry & Biology

Year:

2010

Language:

english

File:

PDF, 764 KB

english, 2010

22

Regiochemical control of monolignol radical coupling: A new paradigm for lignin and lignan biosynthesis

David R Gang, Michael A Costa, Masayuki Fujita, Albena T Dinkova-Kostova, Huai-Bin Wang, Vincent Burlat, William Martin, Simo Sarkanen, Laurence B Davin, Norman G Lewis

Journal:

Chemistry & Biology

Year:

1999

Language:

english

File:

PDF, 3.82 MB

english, 1999

23

The cytoprotective role of the Keap1–Nrf2 pathway

Liam Baird, Albena T. Dinkova-Kostova

Journal:

Archives of Toxicology

Year:

2011

Language:

english

File:

PDF, 1.04 MB

english, 2011

24

Glutathione S-transferase genotype is associated with sensitivity to psoralen–ultraviolet A photochemotherapy

S.H. Ibbotson, R.S. Dawe, A.T. Dinkova-Kostova, S. Weidlich, P.M. Farr, J. Ferguson, C.R. Wolf, G. Smith

Journal:

British Journal of Dermatology

Year:

2012

Language:

english

File:

PDF, 348 KB

english, 2012

25

Precise determination of the erythema response of human skin to ultraviolet radiation and quantification of effects of protectors

Zachary R. Healy, Albena T. Dinkova-Kostova, Scott L. Wehage, Richard E. Thompson, Jed W. Fahey, Paul Talalay

Journal:

Photodermatology, Photoimmunology & Photomedicine

Year:

2009

Language:

english

File:

PDF, 317 KB

english, 2009

26

Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders

Calabrese, Vittorio, Cornelius, Carolin, Dinkova-Kostova, Albena T., Calabrese, Edward J., Mattson, Mark P.

Journal:

Antioxidants & Redox Signaling

Year:

2010

Language:

english

File:

PDF, 1.94 MB

english, 2010

27

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

Hayes, John D., McMahon, Michael, Chowdhry, Sudhir, Dinkova-Kostova, Albena T.

Journal:

Antioxidants & Redox Signaling

Year:

2010

Language:

english

File:

PDF, 1.23 MB

english, 2010

28

Novel semisynthetic analogues of betulinic acid with diverse cytoprotective, antiproliferative, and proapoptotic activities

Liby, K., Honda, T., Williams, C. R., Risingsong, R., Royce, D. B., Suh, N., Dinkova-Kostova, A. T., Stephenson, K. K., Talalay, P., Sundararajan, C.

Journal:

Molecular Cancer Therapeutics

Year:

2007

Language:

english

File:

PDF, 393 KB

english, 2007

29

Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes

Dinkova-Kostova, A. T.

Journal:

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

30

Protection against electrophile and oxidative stress by induction of phase 2 genes: the quest for the elusive sensor that responds to inducers

W.David Holtzclaw, Albena T. Dinkova-Kostova, Paul Talalay

Journal:

Advances in Enzyme Regulation

Year:

2004

Language:

english

File:

PDF, 481 KB

english, 2004

31

Potency ranking of triterpenoids as inducers of a cytoprotective enzyme and as inhibitors of a cellular inflammatory response via their electron affinity and their electrophilicity index

René V. Bensasson, Vincent Zoete, Gaston Berthier, Paul Talalay, Albena T. Dinkova-Kostova

Journal:

Chemico-Biological Interactions

Year:

2010

Language:

english

File:

PDF, 666 KB

english, 2010

32

Induction of the Keap1/Nrf2/ARE pathway by oxidizable diphenols

Albena T. Dinkova-Kostova, Xiu Jun Wang

Journal:

Chemico-Biological Interactions

Year:

2011

Language:

english

File:

PDF, 271 KB

english, 2011

33

HSF1-Dependent Upregulation of Hsp70 by Sulfhydryl-Reactive Inducers of the KEAP1/NRF2/ARE Pathway

Ying Zhang, Young-Hoon Ahn, Ivor J. Benjamin, Tadashi Honda, Ronald J. Hicks, Vittorio Calabrese, Philip A. Cole, Albena T. Dinkova-Kostova

Journal:

Chemistry & Biology

Year:

2011

Language:

english

File:

PDF, 896 KB

english, 2011

34

Redox ranking of inducers of a cancer-protective enzyme via the energy of their highest occupied molecular orbital

Vincent Zoete, Michel Rougée, Albena T. Dinkova-Kostova, Paul Talalay, René V. Bensasson

Journal:

Free Radical Biology and Medicine

Year:

2004

Language:

english

File:

PDF, 452 KB

english, 2004

35

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis

Sudhir Chowdhry, Maiiada H. Nazmy, Paul J. Meakin, Albena T. Dinkova-Kostova, Shaun V. Walsh, Tadayuki Tsujita, John F. Dillon, Michael L.J. Ashford, John D. Hayes

Journal:

Free Radical Biology and Medicine

Year:

2010

Language:

english

File:

PDF, 1.98 MB

english, 2010

36

Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis

Paul Talalay, Albena T Dinkova-Kostova, W.David Holtzclaw

Journal:

Advances in Enzyme Regulation

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

37

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector

Albena T. Dinkova-Kostova, Paul Talalay

Journal:

Archives of Biochemistry and Biophysics

Year:

2010

Language:

english

File:

PDF, 514 KB

english, 2010

38

A dicyanotriterpenoid induces cytoprotective enzymes and reduces multiplicity of skin tumors in UV-irradiated mice

Albena T. Dinkova-Kostova, Stephanie N. Jenkins, Scott L. Wehage, David L. Huso, Andrea L. Benedict, Katherine K. Stephenson, Jed W. Fahey, Hua Liu, Karen T. Liby, Tadashi Honda, Gordon W. Gribble, Mi

Journal:

Biochemical and Biophysical Research Communications

Year:

2008

Language:

english

File:

PDF, 480 KB

english, 2008

39

Protection against UV-light-induced skin carcinogenesis in SKH-1 high-risk mice by sulforaphane-containing broccoli sprout extracts

Albena T. Dinkova-Kostova, Stephanie N. Jenkins, Jed W. Fahey, Lingxiang Ye, Scott L. Wehage, Karen T. Liby, Katherine K. Stephenson, Kristina L. Wade, Paul Talalay

Journal:

Year:

2006

Language:

english

File:

PDF, 230 KB

english, 2006

40

Bis(2-hydroxybenzylidene)acetone, a potent inducer of the phase 2 response, causes apoptosis in mouse leukemia cells through a p53-independent, caspase-mediated pathway

Albena T. Dinkova-Kostova, Ann H. Cory, Richard E. Bozak, Ronald J. Hicks, Joseph G. Cory

Journal:

Year:

2007

Language:

english

File:

PDF, 277 KB

english, 2007

41

Rapid body weight gain increases the risk of UV radiation–induced skin carcinogenesis in SKH-1 hairless mice

Albena T. Dinkova-Kostova, Jed W. Fahey, Stephanie N. Jenkins, Scott L. Wehage, Paul Talalay

Journal:

Nutrition Research

Year:

2008

Language:

english

File:

PDF, 222 KB

english, 2008

42

Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans

Lingxiang Ye, Albena T Dinkova-Kostova, Kristina L Wade, Yuesheng Zhang, Theresa A Shapiro, Paul Talalay

Journal:

Clinica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

43

Erratum to “Quantitative determination of dithiocarbamates in human plasma, serum, erythrocytes and urine: pharmacokinetics of broccoli sprout isothiocyanates in humans” [Clin. Chim. Acta 316 (2002) 43–53]

Lingxiang Ye, Albena T. Dinkova-Kostova, Kristina L. Wade, Yuesheng Zhang, Theresa A. Shapiro, Paul Talalay

Journal:

Clinica Chimica Acta

Year:

2002

Language:

english

File:

PDF, 51 KB

english, 2002

44

Nitric Oxide in Cell Survival: A Janus Molecule

Calabrese, Vittorio, Cornelius, Carolin, Rizzarelli, Enrico, Owen, Joshua B., Dinkova-Kostova, Albena T., Butterfield, D. Allan

Journal:

Antioxidants & Redox Signaling

Year:

2009

Language:

english

File:

PDF, 500 KB

english, 2009

45

Protection against UV-light-induced skin carcinogenesis by topical or dietary administration of broccoli sprout extracts as a source of sulforaphane in SKH-1 high-risk mice

A.T. Dinkova-Kostova, S.N. Jenkins, J.W. Fahey, L. Ye, S.L. Wehage, P. Talalay

Journal:

European Journal of Cancer Supplements

Year:

2006

Language:

english

File:

PDF, 252 KB

english, 2006

46

Diffusion dynamics of the Keap1–Cullin3 interaction in single live cells

Baird, Liam, Dinkova-Kostova, Albena T.

Journal:

Biochemical and Biophysical Research Communications

Year:

2013

Language:

english

File:

PDF, 1.71 MB

english, 2013

47

Chemoprotective Properties of Phenylpropenoids, Bis(benzylidene)cycloalkanones, and Related Michael Reaction Acceptors: Correlation of Potencies as Phase 2 Enzyme Inducers and Radical Scavengers †

Dinkova-Kostova, Albena T., Abeygunawardana, Chitrananda, Talalay, Paul

Journal:

Journal of Medicinal Chemistry

Year:

1998

Language:

english

File:

PDF, 362 KB

english, 1998

48

Safety, Tolerance, and Metabolism of Broccoli Sprout Glucosinolates and Isothiocyanates: A Clinical Phase I Study

Shapiro, Theresa A., Fahey, Jed W., Dinkova-Kostova, Albena T., Holtzclaw, W. David, Stephenson, Katherine K., Wade, Kristina L., Ye, Lingxiang, Talalay, Paul

Journal:

Nutrition and Cancer

Year:

2006

Language:

english

File:

PDF, 839 KB

english, 2006

49

Synthesis and biological evaluation of biotin conjugates of (±)-(4bS,8aR,10aS)-10a-ethynyl-4b,8,8-trimethyl-3,7-dioxo-3,4b,7,8,8a,9,10,10a-octahydro-phenanthrene-2,6-dicarbonitrile, an activator of the Keap1/Nrf2/ARE pathway, for the isolation of its protein targets

Saito, Akira, Higgins, Maureen, Zheng, Suqing, Li, Wei, Ojima, Iwao, Dinkova-Kostova, Albena T., Honda, Tadashi

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 543 KB

english, 2013

50

[Methods in Enzymology] Quinones and Quinone Enzymes, Part B Volume 382 || Chemical Structures of Inducers of Nicotinamide Quinone Oxidoreductase 1 (NQO1)

Dinkova-Kostova, Albena T

Year:

2004

Language:

english

File:

PDF, 238 KB

english, 2004